the normal liver architecture in histopathology. The observed effect may be due to

the antioxidative potential of geniposide (Chen et al. 2016).

29.2.7.13 Resveratrol

Resveratrol is a polyphenolic compound present in berries and grapes mainly. Many

studies have shown the hepatoprotective properties of resveratrol (Chan et al. 2011).

It shows hepatoprotective effects in N-nitrosodiethylamine-induced hepatocellular

carcinoma through inflammatory cytokines and free radicals, induces antioxidant

enzymes, elevates glutathione content and also modulates various signal transduc-

tion pathways of liver diseases. Resveratrol reduces TNF-α IL-6 mRNA and also

decreases the Kupffer cells hired in injured liver (Rajasekaran et al. 2011)

(Fig. 29.2).

29.3

Conclusions

The liver is a vital organ of human body that performs diverse physiological

functions and supports food digestion through bile secretion, metabolism of food

and drugs, detoxification of xenobiotics, storage of glycogen and many other

important functions. Hepatotoxicity or pathological liver damage can occur due to

the abuse of some synthetic drugs, excessive use of alcohol, substances of abuse,

idiosyncratic reactions, viral infections and exposure to environmental toxicants or

Fig. 29.2 Graphical abstract of book chapter

29

The Pathophysiology of Liver Disorders and Pharmacotherapy Options with. . .

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